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KMID : 1140120080130010047
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Cancer Prevention Research
2008 Volume.13 No. 1 p.47 ~ p.53
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A Natural Marine Compound Extracted from the Ark Shell, Scapharca Subcrenata, Inhibits in Vivo and in Vitro Angiogenesis
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Yi Eui-Yeun
Park Shi-Young
Choi Jae-Sun
Lim Chi-Won
Kim Yeon-Kye
Park Hee-Yeon
Kim Yung-Jin
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Abstract
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Angiogenesis is an integral process in the growth and spread of solid tumors, and anti-angiogenesis therapy is one of the most promising therapeutic strategies for the treatment of cancer. In this study, we show that a natural marine compound extracted from ark shell, Scapharca subcrenata, has anti-angiogenic activities. Ark shell extract inhibited the proliferation, migration, invasion and tube formation of human umbilical vein endothelial cells (HUVECs), and suppressed the release of matrix metalloproteinase-2 (MMP-2) by HUVECs. In addition, ark shell extract also inhibited in vivo angiogenesis in a mouse Matrigel-plug assay. Taken together, these results suggest that ark shell extract acts as a novel angiogenesis inhibitor and could be further developed as an anticancer agent. (Cancer Prev Res 13, 47-53, 2008)
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KEYWORD
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Marine bio-source, Tumor, Anti-angiogenic drug, Invasion, Shellfish
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